Researchers design the building blocks of synthetic muscle using computational method


Synthetic myosin could one day be used in regenerative medicine and robotics.
Combinations of them perform different muscular functions like maintaining a heartbeat or bearing weight.
This would require a labor-intensive process of nanoscale trial and error that could take years in the laboratory.
Researchers at Carnegie Mellon University’s College of Engineering have taken a multidisciplinary approach to solving this problem.
“This computational method will help us to understand muscle better through one of its building blocks, myosin, and help us toward building synthetic muscle in the future.
How can we understand and treat myosin-related diseases or develop new approaches for motor molecule-based technologies?
Carnegie Mellon experts in computational design and biomechanical engineering are using an interdisciplinary approach to tackle these challenges.
Credit: College of Engineering, Carnegie Mellon UniversityThese findings, which represent a unique collaboration between engineering disciplines, could further impact future applications for understanding and treating myosin -related diseases and developing new approaches for motor molecule-based technologies.
“This work demonstrates that the interface between fields can yield novel approaches to research and new findings that would be difficult to achieve with any one perspective,” said Jonathan Cagan, professor of mechanical engineering.
“We are merging computational mechanical design—which has been used to design a variety of more traditional systems like automobiles and architecture—with biology,” said LeDuc.
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